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Sildenafil Mesylate

Cat. No. M5960

Sildenafil Mesylate Structure
Size Price Availability Quantity
50mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 474.58(free base)
Formula C22H30N6O4S.xCH4O3S
CAS Number 1308285-21-3
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Influence of imatinib at a low dose and sildenafil on pulmonary hypertension in rats.
Jasińska-Stroschein M, et al. Pharmazie. 2015 Jul;70(7):477-9. PMID: 26373209.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sildenafil Mesylate supplier, PDE, inhibitors

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