Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Molecular Weight||474.58(free base)|
|Solubility||100 mg/mL in DMSO|
Influence of imatinib at a low dose and sildenafil on pulmonary hypertension in rats.
Jasińska-Stroschein M, et al. Pharmazie. 2015 Jul;70(7):477-9. PMID: 26373209.
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