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Cat. No. M5264
SH5-07 Structure


Size Price Availability Quantity
10mM/1mL In DMSO USD 320 In stock
2mg USD 133 In stock
5mg USD 240 In stock
10mg USD 387 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In vitro: SH5-07 blocks STAT3 DNA binding activity in vitro and in human glioma, breast, and prostate cancer cells and in v-Src-transformed murine fibroblasts. STAT3-dependent gene transcription is blocked along with Bcl-2, Bcl-xL, Mcl-1, Cyclin D1, c-Myc and Survivin expression. In vivo: In mouse xenograft models of glioma and breast cancer, administration of SH5-07 effectively inhibits tumor growth.

Cell Experiment
Cell lines Normal mouse fibroblasts (NIH3T3)
Preparation method Cells are treated with 0-8 μM agent for 24-48 h. For cell cycle profile analysis, cells are harvested and fixed with 70% ice-cold ethanol and stained with propidium iodide (PI). For apoptosis analysis, cells are collected and stained with FITC-Annexin V using Apoptosis Detection Kit. Both the DNA content of cells and the Annexin V-positive cells are analyzed by FACScan flow cytometer. Cell cycle phase distribution is analyzed using the Cell-Fit program. Data acquisition is gated to exclude cell doublets.
Concentrations 0-8 μM
Incubation time 24-48 h
Animal Experiment
Animal models female athymic nude mice
Formulation 1% DMSO
Dosages 3, 5 or 6 mg/kg
Administration oral gavage/tail vein injection
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 625.61
Formula C29H28F5N3O5S
CAS Number 1456632-41-9
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.
Yue P, et al. Cancer Res. 2016 Feb 1;76(3):652-63. PMID: 26088127.

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Keywords: SH5-07, SH-5-07 supplier, STAT, inhibitors

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