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Scriptaid

Cat. No. M3002
Scriptaid  Structure
Synonym:

Scriptide; GCK1026

Size Price Availability Quantity
5mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.

Protocol
Cell Experiment
Cell lines Human breast cancer cells MDA-MB-231
Preparation method Plating the cells at a cell density of 5000 cells/well in 12 well plates and treating them with scriptaid for up to 3 days. Use a Coulter counter to count the number of cell every day.
Concentrations ~10 μg/mL
Incubation time 3 days
Animal Experiment
Animal models Human breast carcinoma xenografts MDA-MB-231
Formulation DMSO
Dosages 3.5 mg/kg
Administration intraperitoneally for five consecutive days with 2 days rest each week for a total of 4 weeks
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 326.35
Formula C18H18N2O4
CAS Number 287383-59-9
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C
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ACY-738

ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM.

HPOB

HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.

HDAC8-IN-1

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Scriptaid , Scriptide; GCK1026 supplier, HDAC, inhibitors

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