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SCR7

Cat. No. M4807
SCR7 Structure
Synonym:

SCR-7

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 125 In stock
50mg USD 400 In stock
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Quality Control
Biological Activity

SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis.SCR7 blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I. SCR7 inhibits NHEJ in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway. More importantly, SCR7 impedes tumor progression in mouse models and when coadministered with DSB-inducing therapeutic modalities enhances their sensitivity significantly.SCR7 is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside the cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 334.40
Formula C18H14N4OS
CAS Number 1533426-72-0
Purity >99%
Solubility DMSO
Storage at -20°C
Customer Product Validations & Biological Datas
Source Blood (2016). Figure 2. SCR7
Method MTT assay
Cell Lines MM cell lines
Concentrations 20 μg/mL
Incubation Time 0-120 hours
Results Thus, increased apoptosis and cytotoxicity as well as decreased cell viability were observed in RPMI 8226 compared with LR5 cells, especially 72 hours post melphalan treatment.Again, in both cell lines, increased sensitivity towardmelphalanwas observed in the presence of the inhibitors; SCR7 showed the strongest effect.
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References

Pluronic copolymer encapsulated SCR7 as a potential anticancer agent.
John F, et al. Faraday Discuss. 2015;177:155-61. PMID: 25608025.

Enhanced efficacy of pluronic copolymer micelle encapsulated SCR7 against cancer cell proliferation.
John F, et al. Macromol Biosci. 2015 Apr;15(4):521-34. PMID: 25515310.

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression.
Srivastava M, et al. Cell. 2012 Dec 21;151(7):1474-87. PMID: 23260137.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SCR7, SCR-7 supplier, DNA/RNA Synthesis, inhibitors

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