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Scopoletin

Cat. No. M4788
Scopoletin Structure
Synonym:

Gelseminic acid; Chrysatropic acid

Size Price Availability Quantity
20mg USD 40  USD40 In stock
100mg USD 100  USD100 In stock
200mg USD 165  USD165 In stock
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Quality Control & Documentation
Biological Activity

Scopoletin is an acetylcholinesterase (AChE) inhibitor.

Chemical Information
CAS Number 92-61-5
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zongmei Wu, et al. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress

[2] Zhongxiang Fan, et al. Scopoletin inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by regulating NF-κB signaling pathway

[3] Wanzeng Zhang, et al. Scopoletin Attenuates Intracerebral Hemorrhage-Induced Brain Injury and Improves Neurological Performance in Rats

[4] Chong Yuan, et al. Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer

[5] Zhixian Shi, et al. Novel Scopoletin Derivatives Kill Cancer Cells by Inducing Mitochondrial Depolarization and Apoptosis

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Keywords: Scopoletin, Gelseminic acid; Chrysatropic acid supplier, AChR/AChE, inhibitors, activators


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