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Scoparone

Cat. No. M3928
Scoparone Structure
Synonym:

6,7-Dimethoxycoumarin

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Scoparone markedly reduced the serum-stimulated accumulation of cells in the S phase and concomitantly increased the proportion of cells in the G0/G1 phase, which was consistent with the reduced expression of cyclin D1, phosphorylated Rb and survivin in the VSMCs. Cell adhesion markers, such as MCP-1 and ICAM-1, were significantly reduced by scoparone. Scoparone blocks the accumulation of STAT3 transported from the cytosol to the nucleus, leading to the suppression of VSMC proliferation through G1 phase arrest and the inhibition of Rb phosphorylation. Scoparone elicits an anti-tumor effect against DU145 prostate cancer cells in part through inhibition of STAT3 activity. Therapeutic effect of scoparone could regulated the dysfunctions of citrate cycle, sphingolipid metabolism, taurine and hypotaurine. Scoparone treatment remarkably attenuated LPS-induced pulmonary edema, histological severities, myeloperoxidase activity, and TNF-α, IL-6 and IL-1β production in vivo. Scoparone inhibited LPS-induced TLR4 expression, NF-κB activation, TNF-α, IL-6 and IL-1β production in alveolar macrophages in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 206.19
Formula C11H10O4
CAS Number 120-08-1
Purity >99%
Solubility DMSO 15 mg/mL
Storage at -20°C
References

Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells.
Park S, et al. Exp Mol Med. 2015 Mar 6;47:e145. PMID: 25744297.

Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity.
Zhang A, et al. Sci Rep. 2014 Oct 24;4:6768. PMID: 25341677.

Protective effects of scoparone against lipopolysaccharide-induced acute lung injury.
Niu N, et al. Int Immunopharmacol. 2014 Nov;23(1):127-33. PMID: 25151099.

[Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats].
Cheng L, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2. PMID: 24620662.

Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity.
Kim JK, et al. PLoS One. 2013 Nov 15;8(11):e80391. PMID: 24260381.

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Keywords: Scoparone, 6,7-Dimethoxycoumarin supplier, STAT, inhibitors

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