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Salvianolic acid Y

Cat. No. M18503
Salvianolic acid Y Structure
Size Price Availability Quantity
5mg USD 880  USD880 In stock
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Quality Control & Documentation
Biological Activity

Salvianolic acid Y is a phenolic acid which can rescue cell injury by H2O2.

Chemical Information
Molecular Weight 718.61
Formula C36H30O16
CAS Number 1638738-76-7
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yao-Lei Li, et al. Zhongguo Zhong Yao Za Zhi. [Study on application of salvianolic acids reference extract in quality control of Salvia miltiorrhiza and salvianolic acids for injection]

[2] Wei Li, et al. Phytomedicine. A quality marker study on salvianolic acids for injection

[3] Xialin Chen, et al. J Pharm Biomed Anal. Quantitative analysis of highly similar salvianolic acids with 1H qNMR for quality control of traditional Chinese medicinal preparation Salvianolate Lyophilized Injection

[4] Jun Gong, et al. Molecules. Salvianolic acid Y: a new protector of PC12 cells against hydrogen peroxide-induced injury from Salvia officinalis

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