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ROS inducer 3

Cat. No. M42052
ROS inducer 3 Structure
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Biological Activity

ROS inducer 3 is a ROS inducer.

Chemical Information
Molecular Weight 401.42
Formula C22H22F3N3O
CAS Number 2921602-09-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Javier Florido et al. J Pineal Res. Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport

[2] Alexander Gluschko et al. Autophagy. Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways

[3] Shaohong Fang et al. Cell Death Dis. Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway

[4] Jonghoon Kim et al. ACS Nano. Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

[5] Nianyu Li et al. J Biol Chem. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

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Keywords: ROS inducer 3 supplier, ROS, inhibitors, activators

 
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