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Radotinib

Cat. No. M5916
Radotinib Structure
Synonym:

IY-5511

Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 135 In stock
50mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 530.50
Formula C27H21F3N8O
CAS Number 926037-48-1
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors.
Kim SH, et al. Haematologica. 2014 Jul;99(7):1191-6. PMID: 24705186.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Radotinib, IY-5511 supplier, Src-bcr-Abl, inhibitors

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