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(R)-(+)-Corypalmine

Cat. No. M4735
(R)-(+)-Corypalmine Structure
Size Price Availability Quantity
20mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Corypalmine is an alkaloid from Corydalis chaerophylla. Corypalmine is an antifungal drug.

Chemical Information
Molecular Weight 341.40
Formula C20H23NO4
CAS Number 13063-54-2
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yongping Zhang, et al. Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method

[2] Haiya Wu, et al. Determination of corypalmine in mouse blood by UPLC-MS/MS and its application to a pharmacokinetic study

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