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Indigo

Cat. No. M16201
Indigo Structure
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Quality Control & Documentation
Biological Activity

Indigo

Chemical Information
CAS Number 482-89-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kasumi Nakagawa, et al. J Biosci Bioeng. Voltammetric in-situ monitoring of leuco-indigo in indigo-fermenting suspensions

[2] Koki Kawanishi, et al. Scand J Gastroenterol. Oral indigo carmine for the detection of colon adenoma

[3] Yi-Ming Zhang, et al. Zhongguo Zhong Yao Za Zhi. [Advances in biosynthesis of indigo in plants]

[4] Andrea N Fabara, et al. Appl Microbiol Biotechnol. An overview of microbial indigo-forming enzymes

[5] R M Christie. Biotech Histochem. Why is indigo blue?

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