PZ-128 (P1pal-7), a cell-penetrating peptide, is a first-in-class, specific and reversible protease activating receptor 1 (PAR1) antagonist. It has anti-platelet, anti-metastasis, anti-angiogenesis and anticancer effects.
Molecular Weight | 1086.46 |
Formula | C55H99N13O9 |
CAS Number | 371131-16-7 |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Emily Michael, et al. Methods Mol Biol. Lipopeptide Pepducins as Therapeutic Agents
Related PAR Products |
---|
TRAP-6 amide
TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide. |
Protease-Activated Receptor-1, PAR-1 Agonist
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. |
FSLLRY-NH2
FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor. |
iso-TRAP-6
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. |
PAR-4 Agonist Peptide, amide
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.