Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family. Praeruptorin C can reduce vascular hypertrophy in isolated rat hypertrophied smooth muscle cells, and this is associated with improvement of smooth muscle cells [Ca2+]i level, nitric oxide content and cellular signal transdution of protein kinase C and Gi.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors.
Yang L, et al. Toxicol In Vitro. 2013 Mar;27(2):908-14. PMID: 23313464.
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