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PJ34

Cat. No. M2951
PJ34 Structure
Size Price Availability Quantity
10mg USD 75 In stock
50mg USD 220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PJ-34 is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 295.34
Formula C17H17N3O2
CAS Number 344458-19-1
Purity >98%
Solubility DMSO 10 mg/mL
Storage at -20°C
Related PARP Products
Benzamide

Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.

Picolinamide

Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Niraparib (MK-4827) tosylate

Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.

Daidzein

Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator.

NMS-P118

NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PJ34 supplier, PARP, inhibitors

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