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PJ34 hydrochloride

Cat. No. M2056
PJ34 hydrochloride Structure
Size Price Availability Quantity
10mg USD 60 In stock
25mg USD 120 In stock
50mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PJ34 hydrochloride is a potent, selective PARP-1 inhibitor. PJ34 displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively). PJ34 significantly suppresses HepG2 cell growth in a dose-dependent manner, and inhibits HepG2 cell-derived tumor growth in nude mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 331.8
Formula C17H17N3O2.HCl
CAS Number 344458-15-7
Purity >98%
Solubility DMSO
Water
Storage at -20°C
References

Identification of pim kinases as novel targets for PJ34 with confounding effects in PARP biology.
Antolín AA, et al. ACS Chem Biol. 2012 Dec 21;7(12):1962-7. PMID: 23025350.

PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells.
Huang SH, et al. Oncol Rep. 2008 Sep;20(3):567-72. PMID: 18695907.

Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
Abdelkarim GE, et al. Int J Mol Med. 2001 Mar;7(3):255-60. PMID: 11179503.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PJ34 hydrochloride supplier, PARP, inhibitors

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