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Pirarubicin HCl

Cat. No. M5882
Pirarubicin HCl Structure
Synonym:

THP Hydrochloride

Size Price Availability
10mg USD 100  USD100 Out of stock
50mg USD 310  USD310 Out of stock
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Quality Control & Documentation
Biological Activity

Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.

Chemical Information
Molecular Weight 664.1
Formula C32H38ClNO12
CAS Number 95343-20-7
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Li K, et al. Biochem Biophys Res Commun. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells.

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Keywords: Pirarubicin HCl, THP Hydrochloride supplier, Topoisomerase, inhibitors, activators


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