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Pimobendan

Cat. No. M3434

Pimobendan Structure
Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 220 In stock
50mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pimobendan (Vetmedin) is a Ca (2+) sensitizer with an IC50 of 26 uM and a selective phosphodiesterase III inhibitor with an IC50 of <1 uM. The inhibitory effects of pimobendan on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. Pimobendan decreased the catecholamine secretion (IC (50)=29.5 uM) elicited by carbachol, an agonist at nicotinic acetylcholine receptors, but not that elicited by veratridine, an activator of voltage-dependent Na (+) channels, or by high K (+), an activator of voltage-dependent Ca (2+) channels. Pimobendan also inhibited carbachol-induced influx of Na (+) (IC (50)=25.9 uM) and Ca (2+) (IC (50)=26.0 uM), but not veratridine-induced Na (+) influx or high K (+)-induced Ca (2+) influx.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male DBA/2 mice of viral myocarditis
Formulation Prepared as an oral suspension in 0.25% methylcellulose solution, in concentrations of 120 μg/mL and 12 μg/mL
Dosages 0.1 or 1 mg/kg
Administration Orally once daily
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 334.37
Formula C19H18N4O2
CAS Number 74150-27-9
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pimobendan supplier, PDE, inhibitors

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