Free shipping on all orders over $ 500

PIK-90

Cat. No. M1896
PIK-90 Structure
Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 180  USD180 In stock
100mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PIK-90 is a novel and potent PI3K inhibitor with IC50 values of 11 nM, 350 nM, 18 nM and 58 nM for p110α, p110β, p110γ and p110δ respectively. Phosphoinositide 3-kinases (PI3Ks) are among the most frequently activated signaling pathways in cancer. Inhibition with p110alpha inhibitor PIK-90 resulted in a significant reduction of chemotaxis and actin polymerization to CXCL12 and reduced migration beneath MSC (pseudoemperipolesis). In suspension and MSC cocultures, PIK-90 was potent inducers of CLL cell apoptosis.

Customer Product Validations & Biological Datas
Source Proc Natl Acad Sci U S A (2012). Figure 1.PIK-90
Method apoptosis assay
Cell Lines PTENWT and PTENMT glioma cell lines
Concentrations 0.5 μM
Incubation Time 24 h
Results Like PIK-90, PI-103, and LY294002, PIK-75 could block phosphorylation of Akt
Protocol (for reference only)
Cell Experiment
Cell lines LN229:EGFR (PTENwt) and U87:EGFR (PTENmt) cells
Preparation method Cell proliferation assay and flow cytometry. For viability, 105 cells were seeded in 12-well plates in the presence of erlotinib, PI-103, PIK-90, rapamycin, erlotinib plus PIK-90, erlotinib plus rapamycin, erlotinib plus PIK-90, and rapamycin or erlotinib plus PI-103 for 72 h. Cell viability was determined using a WST-1 assay (Roche Molecular Biochemicals).
Concentrations 0, 0.1, 0.5, 1µM
Incubation time 72h
Animal Experiment
Animal models Human primary GBM43 cells female BALB/c nu/nu mice bearing xenografts model
Formulation DMSO:H20
Dosages 40 mg/kg
Administration daily i.p.
Chemical Information
Molecular Weight 351.36
Formula C18H17N5O3
CAS Number 677338-12-4
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Niedermeier M, et al. Blood. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.

Related PI3K Products
SNV4818

SNV4818 is a potential best-in-class (best-in-class) mutation-selective PI3K-α inhibitor with excellent selectivity for the H1047X mutant and moderate selectivity for the related E545/542X mutant.

hSMG-1 inhibitor 11j

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM.

RLY-2608

RLY-2608 is a first-in-class, orally active, selective inhibitor of PI3Ka metabolism.

EDI048

EDI048 is an orally active Cryptosporidium PI4K inhibitor for the research of cryptosporidiosis.

PI3Kδ-IN-13

PI3Kδ-IN-13 is a PI3Kδ inhibitor (IC50=2.6 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: PIK-90 supplier, PI3K, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.