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p-Coumaryl alcohol

Cat. No. M17406
p-Coumaryl alcohol Structure
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Biological Activity

p-Coumaryl alcohol

Chemical Information
CAS Number 3690-05-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shaoxiang Lee, et al. Carbohydr Polym. Characterization of polyvinyl alcohol/starch composite films incorporated with p-coumaric acid modified chitosan and chitosan nanoparticles: A comparative study

[2] Yanhui Sun, et al. Chemosphere. Quantum chemical calculations on the mechanism and kinetics of ozone-initiated removal of p-coumaryl alcohol in the atmosphere

[3] Philana V van Summeren-Wesenhagen, et al. Microb Cell Fact. Combinatorial optimization of synthetic operons for the microbial production of p-coumaryl alcohol with Escherichia coli

[4] Frank Jansen, et al. Biotechnol Appl Biochem. Metabolic engineering for p-coumaryl alcohol production in Escherichia coli by introducing an artificial phenylpropanoid pathway

[5] Chirantha P Rodrigo, et al. J Am Chem Soc. Single-conformation ultraviolet and infrared spectra of jet-cooled monolignols: p-coumaryl alcohol, coniferyl alcohol, and sinapyl alcohol

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