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Triandrin

Cat. No. M17423
Triandrin Structure
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Biological Activity

Triandrin

Chemical Information
CAS Number 19764-35-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jinze Dou, et al. J Agric Food Chem. Effect of Hybrid Type and Harvesting Season on Phytochemistry and Antibacterial Activity of Extracted Metabolites from Salix Bark

[2] Clarice Noleto-Dias, et al. Molecules. Phenylalkanoid Glycosides (Non-Salicinoids) from Wood Chips of Salix triandra × dasyclados Hybrid Willow

[3] Alexander Panossian, et al. Phytomedicine. Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: an interactive pathway analysis of the downstream effects using RNA microarray data

[4] Loretta Pobłocka-Olech, et al. J Sep Sci. Chromatographic analysis of salicylic compounds in different species of the genus Salix

[5] A Panossian, et al. Phytother Res. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration

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