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β-Asarone

Cat. No. M17420
β-Asarone Structure
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Biological Activity

β-Asarone (Liquid)

Chemical Information
CAS Number 5273-86-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jian Zou, et al. Chin J Nat Med. Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875

[2] Miaomiao Meng, et al. Front Pharmacol. β-Asarone Ameliorates β-Amyloid-Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway

[3] Yulu Zhang, et al. Pharmacol Res. Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder

[4] Thomas Uebel, et al. J Appl Toxicol. α-Asarone, β-asarone, and γ-asarone: Current status of toxicological evaluation

[5] Ranjithkumar Chellian, et al. Phytomedicine. Pharmacology and toxicology of α- and β-Asarone: A review of preclinical evidence

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