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OTSSP167

Cat. No. M2902
OTSSP167 Structure
Synonym:

MELK inhibitor

Size Price Availability
5mg USD 180 4-7 Days
10mg USD 290 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 487.42
Formula C25H28Cl2N4O2
CAS Number 1431697-89-0
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: OTSSP167, MELK inhibitor supplier, AMPK, inhibitors

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