Free shipping on all orders over $ 500


Cat. No. M6254
OSS_128167 Structure

SIRT6-IN-1; OSS-128167

Size Price Availability Quantity
5mg USD 115 In stock
10mg USD 190 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

OSS-128167 proves to be a selective compounds toward SIRT6, its IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression.

Cell Experiment
Cell lines BxPC3 cells
Preparation method 4 × 10^5 BxPC3 cells are plated in six-well plates and allowed to adhere for 24 h. There after, cells are stimulated with 100 μM OSS-128167 or the respective amounts of vehicle DMSO for the indicated time amounts. Finally, cells are used for protein lysate generation, and total H3 and acetylated H3K9 levels are detected by immunoblotting.
Concentrations 100 μM
Incubation time 0, 2, 6, 18, 24 h
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 366.32
Formula C19H14N2O6
CAS Number 887686-02-4
Purity 99.96%
Solubility 60 mg/mL in DMSO
Storage at -20°C

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Cea M, et al. Blood. 2016 Mar 3;127(9):1138-50. PMID: 26675349.

Discovery of novel and selective SIRT6 inhibitors.
Parenti MD, et al. J Med Chem. 2014 Jun 12;57(11):4796-804. PMID: 24785705.

Related Sirtuin Products

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.


SRT2104 is a selective brain-permeable activator of SIRT1.


3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively.

Salvianolic acid B

Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease.

Tenovin 6 Hydrochloride

Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.

Abmole Inhibitor Catalog 2017

Keywords: OSS_128167, SIRT6-IN-1; OSS-128167 supplier, Sirtuin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.