Norepinephrine directly stimulates adrenergic receptors. Stimulation of beta-1 adrenergic receptors causes an increase in myocardial contractility, heart rate, automaticity, and atrioventricular (AV) conduction while stimulation of beta-2 adrenergic receptors causes bronchiolar and vascular smooth muscle dilatation.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 10 mM|
Suppression of Resting Metabolism by the Angiotensin AT2 Receptor.
Littlejohn NK, et al. Cell Rep. 2016 Aug 9;16(6):1548-1560. PMID: 27477281.
Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes.
MacGregor DA, et al. Chest. 1996 Jan;109(1):194-200. PMID: 8549185.
|Related Adrenergic Receptor Products|
Vibegron is a potent and selective beta 3 adrenergic receptor agonist.
L-755,507 is a very potent and selective β 3 partial agonist.
5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.
Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
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