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Norepinephrine

Cat. No. M9264
Norepinephrine Structure
Synonym:

Levarterenol; Levophed; Arterenol

Size Price Availability Quantity
100mg USD 40 In stock
500mg USD 120 In stock
1g USD 180 In stock
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Quality Control
Biological Activity

Norepinephrine directly stimulates adrenergic receptors. Stimulation of beta-1 adrenergic receptors causes an increase in myocardial contractility, heart rate, automaticity, and atrioventricular (AV) conduction while stimulation of beta-2 adrenergic receptors causes bronchiolar and vascular smooth muscle dilatation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 169.18
Formula C8H11NO3
CAS Number 51-41-2
Purity 99.84%
Solubility Water 20 mM
DMSO 10 mM
Storage at -20°C
References

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor.
Littlejohn NK, et al. Cell Rep. 2016 Aug 9;16(6):1548-1560. PMID: 27477281.

Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes.
MacGregor DA, et al. Chest. 1996 Jan;109(1):194-200. PMID: 8549185.

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  Catalog
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Keywords: Norepinephrine, Levarterenol; Levophed; Arterenol supplier, Adrenergic Receptor, inhibitors

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