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Nitroxoline

Cat. No. M5821
Nitroxoline Structure
Synonym:

8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol

Size Price Availability Quantity
100mg USD 65  USD65 In stock
500mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.

Chemical Information
Molecular Weight 190.16
Formula C9H6N2O3
CAS Number 4008-48-4
Solubility (25°C) 38 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lazovic J, et al. Neuro Oncol. Nitroxoline induces apoptosis and slows glioma growth in vivo.

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Keywords: Nitroxoline, 8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol supplier, Topoisomerase, inhibitors, activators


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