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Nitroxoline

Cat. No. M5821

Nitroxoline Structure

Synonym: 8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol

Size Price Availability Quantity
100mg USD 65 In stock
500mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 190.16
Formula C9H6N2O3
CAS Number 4008-48-4
Purity >99%
Solubility 38 mg/mL in DMSO
Storage at -20°C
References

Nitroxoline induces apoptosis and slows glioma growth in vivo.
Lazovic J, et al. Neuro Oncol. 2015 Jan;17(1):53-62. PMID: 25074541.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nitroxoline, 8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol supplier, Topoisomerase, inhibitors

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