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Nitrofurazone is a topical anti-infective agent with an IC50 of 22.83 ?1.2 uM, and effective against gram-negative and gram-positive bacteria. (Rat LD50 = 590 mg/kg) Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ?1.2 uM and 10.55 ?0.81 uM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory activity.
| Molecular Weight | 198.14 |
| Formula | C6H6N4O4 |
| CAS Number | 59-87-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Med Klin. FURACIN
[2] D R Guay. An update on the role of nitrofurans in the management of urinary tract infections
[3] E Volles, et al. Nitrofural (Furacin) polyneuropathy
[4] H Kala, et al. Therapeutically used 5-nitrofural derivatives. Review of literature. 2
[5] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Nitrofural (nitrofurazone)
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