Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections. Teicoplanin is a semisynthetic glycopeptide antibiotic with a spectrum of activity similar to vancomycin. Teicoplanin is effective against Gram-positive bacteria resistant to β-lactam antibiotics. Its mechanism of action is to inhibit bacterial cell wall synthesis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water 90 mg/mL|
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.
Li TL, et al. Chem Biol. 2004 Jan;11(1):107-19. PMID: 15113000.
Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.
Sosio M, et al. Microbiology. 2004 Jan;150(Pt 1):95-102. PMID: 14702401.
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