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Teicoplanin

Cat. No. M2009
Teicoplanin Structure
Synonym:

Targocid, Teichomycin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 59.4  USD66 In stock
100mg USD 91.8  USD102 In stock
500mg USD 295.2  USD328 In stock
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Quality Control
Biological Activity

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections. Teicoplanin is a semisynthetic glycopeptide antibiotic with a spectrum of activity similar to vancomycin. Teicoplanin is effective against Gram-positive bacteria resistant to β-lactam antibiotics. Its mechanism of action is to inhibit bacterial cell wall synthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1709.39
Formula C77H77N9O31Cl2·R
CAS Number 61036-62-2
Purity Potency >900ug/mg
Solubility Water 90 mg/mL
Storage at -20°C
References

Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.
Li TL, et al. Chem Biol. 2004 Jan;11(1):107-19. PMID: 15113000.

Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.
Sosio M, et al. Microbiology. 2004 Jan;150(Pt 1):95-102. PMID: 14702401.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Teicoplanin, Targocid, Teichomycin supplier, Anti-infection, inhibitors

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