Free shipping on all orders over $ 500

Nisoldipine

Cat. No. M3462

Nisoldipine Structure
Size Price Availability Quantity
1g USD 200 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Nisoldipine (Sular) is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, it relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload . [1, 2]

Protocol
Cell Experiment
Cell lines Ventricular myocytes
Preparation method Bathing the myocytes in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, recording tail currents on repolarisations to -40mV. Exposing the myocytes to 10-100 mM Nisoldipine for 8-10 minutes. Then using an EPC-7 amplifier to record the whole-cell membrane currents.
Concentrations Dissolved in DMSO, final concentration 10-100 μM
Incubation time 8-10 minutes
Animal Experiment
Animal models Male Wistar rats with chronic intragastric ethanol exposure
Formulation Dissolved in DMSO and diluted in saline
Dosages 10 mg/kg
Administration Oral every day
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 388.41
Formula C20H24N2O6
CAS Number 63675-72-9
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
Related Calcium Channel Products
Mirogabalin

Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS.

Ranolazine

Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.

L-Phenylalanine

L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.

Levosimendan

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

Lercanidipine

Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nisoldipine supplier, Calcium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.