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Cat. No. M3462
Nisoldipine Structure

BAY-k 5552

Size Price Availability Quantity
100mg USD 50 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nisoldipine (Sular) is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, it relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload . [1, 2]

Cell Experiment
Cell lines Ventricular myocytes
Preparation method Bathing the myocytes in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, recording tail currents on repolarisations to -40mV. Exposing the myocytes to 10-100 mM Nisoldipine for 8-10 minutes. Then using an EPC-7 amplifier to record the whole-cell membrane currents.
Concentrations Dissolved in DMSO, final concentration 10-100 μM
Incubation time 8-10 minutes
Animal Experiment
Animal models Male Wistar rats with chronic intragastric ethanol exposure
Formulation Dissolved in DMSO and diluted in saline
Dosages 10 mg/kg
Administration Oral every day
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 388.41
Formula C20H24N2O6
CAS Number 63675-72-9
Purity >98%
Solubility DMSO 70 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: Nisoldipine, BAY-k 5552 supplier, Calcium Channel, inhibitors

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