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Azelnidipine

Cat. No. M2425

Azelnidipine Structure

Synonym: UR-12592

Size Price Availability Quantity
50mg USD 240 In stock
100mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Azelnidipine is a dihydropyridine calcium channel blocker.Azelnidipine is a newly developed long-acting calcium channel blocker with unique pharmacological features, e.g. cardiac slowing action and high affinity to vascular tissues, which distinguishes itself from other calcium channel blockers. Azelnidipine, thus, became a new generation of calcium channel blocker that can be used for the treatment of hypertensive patients with or without potential ischemic heart diseases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 582.65
Formula C33H34N4O6
CAS Number 123524-52-7
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
References

Azelnidipine and amlodipine: a comparison of their pharmacokinetics and effects on ambulatory blood pressure.
Kuramoto K, et al. Hypertens Res 2003 Mar;26(3):201-8. PMID: 12675275.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Azelnidipine, UR-12592 supplier, Calcium Channel, inhibitors

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