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Nimbin

Cat. No. M17869
Nimbin Structure
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Biological Activity

Nimbin

Chemical Information
CAS Number 5945-86-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gokul Sudhakaran, et al. Toxicol Appl Pharmacol. Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels

[2] Gokul Sudhakaran, et al. Mol Cell Biochem. Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model

[3] Arquimedes Gasparotto Junior, et al. Curr Pharm Des. Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections

[4] Varsha Sharma, et al. Int J Pharm. Multilayer capsules encapsulating nimbin and doxorubicin for cancer chemo-photothermal therapy

[5] P Lavanya, et al. Virusdisease. Computational analysis reveal inhibitory action of nimbin against dengue viral envelope protein

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