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Mogrol

Cat. No. M17866
Mogrol Structure
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Biological Activity

Mogrol

Chemical Information
CAS Number 88930-15-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jing-Ru Song, et al. Bioorg Med Chem Lett. Synthesis and anti-proliferation activity of mogrol derivatives bearing quinoline and triazole moieties

[2] Han Liang, et al. Phytomedicine. Mogrol, an aglycone of mogrosides, attenuates ulcerative colitis by promoting AMPK activation

[3] Hui Wang, et al. J Asian Nat Prod Res. Mogrol attenuates lipopolysaccharide (LPS)-induced memory impairment and neuroinflammatory responses in mice

[4] Lei Wang, et al. J Asian Nat Prod Res. Separation, synthesis, and cytotoxicity of a series of mogrol derivatives

[5] Gangling Chen, et al. J Pharm Pharmacol. Neuroprotective effect of mogrol against Aβ 1-42 -induced memory impairment neuroinflammation and apoptosis in mice

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