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Mutanocyclin

Cat. No. M40510
Mutanocyclin Structure
Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 300  USD300 In stock
25mg USD 450  USD450 In stock
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Biological Activity

Mutanocyclin, a tetramic acids analog, is also a potent antifungal agent that inhibits mycelium formation in Candida albicans. In addition, Mutanocyclin also reduces the mRNA expression of HWP1, ECE1, FLO8, TEC1, and has inhibitory activity against immune cell infiltration.

Chemical Information
Molecular Weight 197.23
Formula C10H15NO3
CAS Number 875455-92-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jonathon L Baker et al. J Bacteriol. mucG, mucH, and mucI Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5

[2] Li Tao et al. Virulence. Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid

[3] Carla Uranga et al. Front Oral Health. Tetramic Acids Mutanocyclin and Reutericyclin A, Produced by Streptococcus mutans Strain B04Sm5 Modulate the Ecology of an in vitro Oral Biofilm

[4] Jonathon L Baker et al. Microbiol Resour Announc. Composite Long- and Short-Read Sequencing Delivers a Complete Genome Sequence of B04Sm5, a Reutericyclin- and Mutanocyclin-Producing Strain of Streptococcus mutans

[5] Xiaoyu Tang et al. ACS Infect Dis. Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization

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