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Cat. No. M5042
MMAD Structure

Monomethyl auristatin D

Size Price Availability Quantity
10mM*1mL In DMSO USD 440 In stock
2mg USD 220 In stock
5mg USD 350 In stock
10mg USD 520 In stock
50mg USD 1560 In stock
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Quality Control
Biological Activity

he linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 compound moieties per antibody molecule.

Customer Product Validations & Biological Datas
Source Ther Adv Respir Dis (2018). Figure 3. MMAD
Method Influence of inhalation duration on lung deposition
Cell Lines mice
Concentrations 1.5, 3.0, 4.5 μM
Incubation Time -
Results Other studies also suggest that particles with an MMAD in the range 1.5–4.5 μm can achieve good lung deposition, consistent with these findings.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 771.06
Formula C41H66N6O6S
CAS Number 203849-91-6
Purity 99.81%
Solubility 10 mM in DMSO
Storage at -20°C
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Keywords: MMAD, Monomethyl auristatin D supplier, Microtubule, inhibitors

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