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ML162

Cat. No. M10587
ML162 Structure
Synonym:

ML-162

Size Price Availability Quantity
5mg USD 194  USD194 In stock
10mg USD 386  USD386 In stock
25mg USD 580  USD580 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 477.40
Formula C23H22Cl2N2O3S
CAS Number 1035072-16-2
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Daiha Shin, et al. Free Radic Biol Med. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

[2] Michel Weiwer, et al. Bioorg Med Chem Lett. Development of small-molecule probes that selectively kill cells induced to express mutant RAS

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Keywords: ML162, ML-162 supplier, Ferroptosis, inhibitors

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