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Mitoxantrone dihydrochloride

Cat. No. M2217

Mitoxantrone dihydrochloride Structure
Size Price Availability Quantity
100mg USD 80 In stock
250mg USD 150 In stock
500mg USD 250 In stock
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Quality Control
Biological Activity

Mitoxantrone dihydrochloride is a potent type II DNA topoisomerase inhibitor. Mitoxantrone dihydrochloride disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells, by intercalation. Mitoxantrone dihydrochloride increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone dihydrochloride also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 517.4
Formula C22H28N4O6.2HCl
CAS Number 70476-82-3
Purity 98.71%
Solubility DMSO
Storage at -20°C
References

Mitoxantrone: a review of its use in multiple sclerosis.
Scott LJ, et al. CNS Drugs. 2004;18(6):379-96. PMID: 15089110.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mitoxantrone dihydrochloride supplier, Topoisomerase, inhibitors

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