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(-)-Rasfonin

Cat. No. M38969
(-)-Rasfonin Structure
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Biological Activity

(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line).

Chemical Information
Molecular Weight 434.57
Formula C25H38O6
CAS Number 303156-68-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] F Zhang et al. Beijing Da Xue Xue Bao Yi Xue Ban. [Rasfonin inhibits proliferation and migration of osteosarcoma 143B cells]

[2] Hui Sun et al. Mycology. Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line

[3] Weijun Wang et al. Mycology. Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway

[4] Q Lu et al. Cell Death Dis. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells

[5] Z Xiao et al. Cell Death Dis. Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice

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Keywords: (-)-Rasfonin supplier, Ras, inhibitors, activators

 
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