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MALT1 inhibitor (MI-2)

Cat. No. M3639
MALT1 inhibitor (MI-2) Structure

ABM-3912; MI-2

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 97  USD97 In stock
2mg USD 53  USD53 In stock
5mg USD 95  USD95 In stock
10mg USD 130  USD130 In stock
50mg USD 450  USD450 In stock
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Quality Control
Biological Activity

MALT1 inhibitor (ABM-3912) binds directly to MALT1 and irreversibly suppresses protease function. MALT1 inhibitor (ABM-3912) decreases NF-κB activity induced by MALT1. MALT1 inhibitor (ABM-3912) inhibits cell proliferation and MALT1-mediated cleavage activity. MALT1 inhibitor (ABM-3912) concentrates within human ABC-DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates. MALT1 inhibitor (ABM-3912) displayes selective activity against ABC-DLBCL cell lines in vitro and xenotransplanted ABC-DLBCL tumors in vivo.

Cell Experiment
Cell lines MLL-AF9 and E2A-HLF transduced murine BMC
Preparation method Plating the MLL-AF9 and E2A-HLF transduced murine BMC in 12-well plates at the concentration of 5×103 cells/mL with 1 mL methylcellulose medium M3234 containing 20% IMDM medium, 1% penicillin/streptomycin, IL-3 and 0.25% DMSO or compounds.After 6 days staining colonies with 100 μL iodonitrotetrazolium chloride at final concentration of 1 mg/mL, incubating at 37°C for 30 min and counting . To replate for the 2nd round, counting colonies at day 6 without staining and washing cells out by 1×PBS buffer and resuspending in IMDM medium which contains 15% FBS, 1% penicillin/streptomycin and IL-3.Plateing 5×103 cells in 12-well plates with 1ml methycellulose medium M3234 containing 20% IMDM medium, 1% penicillin/streptomycin, IL-3 and 0.25% DMSO or compounds. 6 days later staining and counting colonies .
Concentrations ~20 μM
Incubation time 12 days
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 455.72
Formula C19H17Cl3N4O3
CAS Number 1047953-91-2
Purity 99.92%
Solubility DMSO ≥ 35 mg/mL
Storage at -20°C

[1] Fontan L, et al. Cancer Cell. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Abmole Inhibitor Catalog 2017

Keywords: MALT1 inhibitor (MI-2), ABM-3912; MI-2 supplier, MALT1, inhibitors

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