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LY2584702 Tosylate

Cat. No. M4864
LY2584702 Tosylate Structure
Synonym:

LY2584702

Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 135 In stock
50mg USD 400 In stock
100mg USD 630 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 617.62
Formula C28H27F4N7O3S
CAS Number 1082949-68-5
Purity >99%
Solubility DMSO 7 mg/mL
Water <1 mg/mL
Storage at -20°C
References

A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours.
Tolcher A, et.al Eur J Cancer. 2014 Mar;50(5):867-75. PMID: 24440085.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LY2584702 Tosylate, LY2584702 supplier, S6 Kinase, inhibitors

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