Free shipping on all orders over $ 500

PF-4708671

Cat. No. M2271
PF-4708671 Structure
Synonym:

PF-04708671

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 264 In stock
100mg USD 470 In stock
Bulk Inquiry?

Quality Control
Biological Activity

PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1) which specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1, while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 displays no effect on the activity of RSK and MSK in vivo. PF-4708671 exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro. PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 390.41
Formula C19H21F3N6
CAS Number 1255517-76-0
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).
Pearce LR, et al. Biochem J. 2010 Oct 15;431(2):245-55. PMID: 20704563.

Related S6 Kinase Products
LY2584702 Tosylate

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.

LY2584702

LY2584702 is a selective, ATP-competitive p70 S6 kinase inhibitor with IC50 of 4 nM.

SL 0101-1

SL-0101-1 is a selective p90 RSK inhibitor for RSK2 with IC50 of 89 nM.

FMK

FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants.

BI-D1870

BI-D1870 is a small molecule specific inhibitor of the p90 RSK (ribosomal S6 kinase) with an IC50 of 10-30 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PF-4708671, PF-04708671 supplier, S6 Kinase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.