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Lenalidomide hemihydrate

Cat. No. M5732
Lenalidomide hemihydrate Structure
Size Price Availability Quantity
50mg USD 90 In stock
100mg USD 120 In stock
500mg USD 180 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 268.27
Formula C13H14N3O3.5
CAS Number 847871-99-2
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Lenalidomide, an antineoplastic drug, and its hemihydrate.
Ravikumar K, et al. Acta Crystallogr C. 2009 Oct;65(Pt 10):o502-5. PMID: 19805881.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Lenalidomide hemihydrate supplier, TNF-alpha, inhibitors

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