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  Catalog
Abmole Inhibitor Catalog 2017

TNF-alpha TNF-alpha

Inhibitors

Cat.No.  Name Information
M6224 Etanercept Etanercept is a dimeric fusion protein consisting of two ligand-binding domains of human p75 tumor necrosis factor receptor and the human IgG1 Fc portion.
M6222 Adalimumab Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
M5732 Lenalidomide hemihydrate Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
M5385 Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.
M5272 Bioymifi Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.
M5209 GSK481 GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor.
M4974 GW4869 Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood.
M4740 Corilagin Corilagin is an inhibitor of TNF-α, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others.
M2315 Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
M2225 Thalidomide Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.
M1976 Pomalidomide Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.
M1962 Lenalidomide Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.
M1545 Infliximab Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases.


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