Catalog

TNF-alpha TNF-alpha

Inhibitors

Cat.No.	Name	Information
M6222	Adalimumab	Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
M5732	Lenalidomide hemihydrate	Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
M5385	Acetylcysteine	Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.
M5272	Bioymifi	Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.
M5209	GSK481	GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor.
M4974	GW4869	Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood.
M2315	Necrostatin-1	Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
M2225	Thalidomide	Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.
M1976	Pomalidomide	Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.
M1962	Lenalidomide	Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.