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  Catalog
Abmole Inhibitor Catalog 2017

TNF-alpha TNF-alpha

Inhibitors

Cat.No.  Name Information
M5732 Lenalidomide hemihydrate Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
M5385 Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.
M5272 Bioymifi Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.
M5209 GSK481 GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor.
M2315 Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
M2225 Thalidomide Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.
M1976 Pomalidomide Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.
M1962 Lenalidomide Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.


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