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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M6224 | Etanercept | Etanercept is a dimeric fusion protein consisting of two ligand-binding domains of human p75 tumor necrosis factor receptor and the human IgG1 Fc portion. |
| M6222 | Adalimumab | Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD. |
| M5732 | Lenalidomide hemihydrate | Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. |
| M5385 | Acetylcysteine | Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. |
| M5272 | Bioymifi | Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis. |
| M5209 | GSK481 | GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor. |
| M4974 | GW4869 | Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood. |
| M4740 | Corilagin | Corilagin is an inhibitor of TNF-α, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. |
| M2315 | Necrostatin-1 | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
| M2225 | Thalidomide | Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. |
| M1976 | Pomalidomide | Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM. |
| M1962 | Lenalidomide | Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
| M1545 | Infliximab | Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases. |
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