|M6222||Adalimumab||Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.|
|M5732||Lenalidomide hemihydrate||Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.|
|M5385||Acetylcysteine||Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.|
|M5272||Bioymifi||Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.|
|M5209||GSK481||GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor.|
|M4974||GW4869||Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood.|
|M2315||Necrostatin-1||Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.|
|M2225||Thalidomide||Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.|
|M1976||Pomalidomide||Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.|
|M1962||Lenalidomide||Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.|
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