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Abmole Inhibitor Catalog 2017

TNF-alpha TNF-alpha


Cat.No.  Name Information
M10468 N-Formyl-Met-Leu-Phe N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion.
M10324 Cynaropicrin Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release and the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
M9710 Roquinimex Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity.
M6224 Etanercept Etanercept is a dimeric fusion protein consisting of two ligand-binding domains of human p75 tumor necrosis factor receptor and the human IgG1 Fc portion.
M6222 Adalimumab Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
M5732 Lenalidomide hemihydrate Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
M5272 Bioymifi Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.
M5209 GSK481 GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor.
M4974 GW4869 2HCl GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM.
M4740 Corilagin Corilagin is an inhibitor of TNF-α, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others.
M4378 Forsythoside-B Forsythoside-B inhibits TNF-alpha, IL-6, IκB and modulate NF-κB.
M2225 Thalidomide Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.
M1962 Lenalidomide Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.
M1545 Infliximab Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases.

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