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Etanercept

Cat. No. M6224
Etanercept Structure
Size Price Availability Quantity
5mg USD 880 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Etanercept conjugated with IRDye800CW exhibited a D/P ratio of 2.5:1. The measured concentration of the I-E conjugates was 1.01 mg/ml, which is close to the etanercept concentration (1 mg/ml) used in the labeling reaction. This suggests that there was no loss of etanercept during the reaction and purification process.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models CIA rats
Formulation
Dosages 5 mg/kg
Administration s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >99%
Solubility
Storage at -20°C
References

Biodistribution of Etanercept to Tissues and Sites of Inflammation in Arthritic Rats
Chen X, et al. Drug Metab Dispos. 2015 Jun;43(6):898-907. PMID: 25834031.

Efficacy and safety of etanercept in chronic immune-mediated disease.
Murdaca G, et al. Expert Opin Drug Saf. 2014 May;13(5):649-61. PMID: 24654562.

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  Catalog
Abmole Inhibitor Catalog 2017




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