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Shikonin

Cat. No. M4240
Shikonin Structure
Synonym:

C.I. 75535; Isoarnebin 4; CAS# 54952-43-1

Size Price Availability Quantity
10mg USD 43  USD43 In stock
20mg USD 77  USD77 In stock
50mg USD 137  USD137 In stock
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Quality Control & Documentation
Biological Activity

Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), and it can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin also inhibits AIM2 inflammasome activation.

Chemical Information
Molecular Weight 288.30
Formula C16H16O5
CAS Number 517-89-5
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhenzhen Mu, et al. Therapeutic Effects of Shikonin on Skin Diseases: A Review

[2] Qiang Sun, et al. Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

[3] Chuanjie Guo, et al. Pharmacological properties and derivatives of shikonin-A review in recent years

[4] Joelle C Boulos, et al. Shikonin derivatives for cancer prevention and therapy

[5] Hongli Guo, et al. Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation

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Keywords: Shikonin, C.I. 75535; Isoarnebin 4; CAS# 54952-43-1 supplier, TNF Receptor, inhibitors, activators


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