LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. LB-100 increases concentration of doxorubicin within cells (2.5 fold to control) and sensitizes tumor cells to the cytotoxicity of doxorubicin. LB-100 increaseds VEGF secretion, and thus enhances HIF-1α-VEGF mediated angiogenesis.
In vivo, LB-100 (2 mg/kg, i.p.) decreases in a time-dependent manner the activity of PP2A in xenografts and livers in nude mice. The combination of doxorubicin (1.5 kg/mL, every other day) and LB-100 (2 mg/kg, every other day) significantly slows the growth of tumors with reduction of tumor volume in two animals with no effects on tumor growth in animals treated with single agents.
Another CAS# 1632032-53-1
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water ≥ 40 mg/mL|
Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas.
Bai XL, et al. Mol Cancer Ther. 2014 Aug;13(8):2062-72. PMID: 24867249.
1-methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.
Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia.
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
Indole-3-acetamide is an auxin precursor.
|D-Gluconic acid copper(II) salt
D-gluconic acid copper (II) salt is the copper salt of D-gluconic acid that is an organic acid.
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