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KY-226

Cat. No. M9699
KY-226 Structure
Synonym:

KY226

Size Price Availability
5mg USD 160 4-7 Days
10mg USD 270 4-7 Days
25mg USD 480 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 0.25 μM, which protects neurons from cerebral ischemic injury. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 (0.3-10 μM) increases the phosphorylated insulin receptor (pIR) produced by insulin in human hepatoma-derived cells. 

In vivo, KY-226 (10-30 mg/kg/day; oral; for 4 weeks) treatment in male db/db mice significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 481.67
Formula C27H31NO3S2
CAS Number 1621673-53-7
Purity >98%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia
Meiling Sun, et al. Neuroscience. 2019 Feb 10;399:89-102. PMID: 30579831.

Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice
Yuma Ito, et al. J Pharmacol Sci. 2018 May;137(1):38-46. PMID: 29731242.

Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice
Meiling Sun, et al. Brain Res. 2018 Sep 1;1694:1-12. PMID: 29705606.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: KY-226, KY226 supplier, Phosphatase, inhibitors

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