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KN-92

Cat. No. M3866
KN-92 Structure
Size Price Availability Quantity
10mg USD 330 In stock
50mg USD 980 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 456.98
Formula C24H25ClN2O3S
CAS Number 176708-42-2
Purity >98%
Solubility DMSO
Storage at -20°C
References

KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer.
Rokhlin OW, et al. Cancer Biol Ther. 2010 Feb;9(3):224-35. PMID: 20023417.

KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro.
An P, et al. World J Gastroenterol. 2007 Mar 7;13(9):1445-8. PMID: 17457979.

CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.
Gao L, et al. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10. PMID: 16730662.

Related CaMK Products
STO-609 acetate

STO-609 acetate is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ with Ki of 80 and 15 ng/ml, respectively.

KN-92 phosphate

KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93.

KN 93

KN 93 is a caM kinase II inhibitor; also K + channel blocker (K V).

KN-62

KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: KN-92 supplier, CaMK, inhibitors

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