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JNK-IN-8

Cat. No. M2013
JNK-IN-8 Structure
Size Price Availability Quantity
10mg USD 200 In stock
50mg USD 550 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

JNK-IN-8 is a highly selective JNK inhibitor based on multiple profiling strategies. JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively. JNK-IN-8 inhibits c-Jun phosphorylation at submicromolar concentrations in cells. JNK-IN-8 will be broadly useful as a pharmacological probe of JNK-dependent signal transduction.

Customer Product Validations & Biological Datas
Source Chem Biol (2012). Figure 4. JNK-IN-8
Method Western Blot
Cell Lines HEK293- IL1R cells
Concentrations 1.0 μM
Incubation Time 24 h
Results JNK-IN-7, JNK-IN-8, and JNK-IN-12 exhibited only on-pathway activity as monitored by inhibition of c-Jun phosphorylation
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 507.59
Formula C29H29N7O2
CAS Number 1410880-22-6
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery of potent and selective covalent inhibitors of JNK.
Zhang T, et al. Chem Biol. 2012 Jan 27;19(1):140-54. PMID: 22284361.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JNK-IN-8 supplier, JNK, inhibitors

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