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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9718 | DB07268 | DB07268 is is a potent and selective JNK1 inhibitor, with IC50 of 9 nM. |
| M9388 | Tanzisertib | Tanzisertib (CC-930) is a potent JNK1/2/3 inhibitor with IC50s of 61/7/6 nM, respectively. |
| M9176 | DTP3 | DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
| M9175 | Vacquinol-1 | Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. |
| M8946 | IQ-1S | IQ-1S is a potent and selective JNK inhibitor with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively. |
| M8921 | Bentamapimod | Bentamapimod, also known as AS602801, is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively. |
| M5145 | Anisomycin | Anisomycin is a pyrrolidine antibiotic, which inhibits protein synthesis, and also act as a JNK activator. |
| M4340 | Cinobufagin | Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. |
| M3713 | YS-49 | YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity. |
| M2785 | JNK Inhibitor IX | JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. |
| M2076 | SP600125 | SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. |
| M2013 | JNK-IN-8 | JNK-IN-8 is a selective JNK inhibitor that inhibits phosphorylation of c-Jun. |
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