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DB07268

Cat. No. M9718
DB07268 Structure
Synonym:

DB-07268

Size Price Availability Quantity
10mg USD 150  USD150 In stock
50mg USD 550  USD550 In stock
100mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

DB07268 is is a potent and selective JNK1 inhibitor, with IC50 of 9 nM. DB07268 also inhibits CHK1, PAK4, AKT1 and ERK2 with IC50 values of 0.82 μM, 5.5 μM, 15 μM and 25 μM, respectively.

Chemical Information
Molecular Weight 321.33
Formula C17H15N5O2
CAS Number 929007-72-7
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mei Liu, et al. Bioorg Med Chem Lett. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

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  Catalog
Abmole Inhibitor Catalog




Keywords: DB07268, DB-07268 supplier, JNK, inhibitors, activators


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