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Ivacaftor hydrate

Cat. No. M54658

All AbMole products are for research use only, cannot be used for human consumption.

Ivacaftor hydrate Structure
Synonym:

VX-770 hydrate

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Quality Control & Documentation
Biological Activity

Ivacaftor hydrate is an orally active cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis related studies.

Chemical Information
Molecular Weight 410.51
Formula C24H30N2O4
CAS Number 1134822-07-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related CFTR Products
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GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis.

NJH-2-057 

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

GLPG2737

GLPG2737 is a novel potent Type 2 corrector of CFTR. GLPG2737 showed high permeability both in MDCKII-MDRI and Caco-2 cells, with low efflux allowing an elevated absorbed fraction FaxFg and a dose proportional increase in exposure in rat from a dose of 5 to 300 mg/kg, despite a low aqueous thermodynamic solubility.

UCCF-853

UCCF-853 is a cystic fibrosis transmembrane regulatory protein (CFTR) modulator.

(R)-Posenacaftor sodium

(R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF).

  Catalog
Abmole Inhibitor Catalog




Keywords: Ivacaftor hydrate, VX-770 hydrate supplier, CFTR, inhibitors, activators

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